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Así, Amros y Ruvkun se interesaron por cómo se desarrollan los distintos tipos celulares y descubrieron los micro-ARN, una nueva clase de diminutas moléculas de ARN que desempeñan “un papel crucial” en la regulación de los genes.
Comprender la regulación de la actividad de los genes ha sido un objetivo importante durante muchas décadas.
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“El Premio Nobel de este año se centra en el descubrimiento de un mecanismo regulador vital utilizado en las células para controlar la actividad de los genes”, subraya el comunicado, que precisa que la información genética pasa del ADN al ARN mensajero (ARNm) mediante un proceso llamado transcripción, y de ahí a la maquinaria celular para la producción de proteínas.
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Desde entonces, se han identificado miles de factores de transcripción, y durante mucho tiempo se creyó que se habían resuelto los principios fundamentales de la regulación génica.
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